More Warning This medicine may cause very bad and sometimes deadly breathing problems. Call your doctor right away if you have slow, shallow, or trouble breathing. This medicine is a benzodiazepine. The use of a benzodiazepine drug along with opioid drugs has led to very bad side effects. Side effects that have happened include slowed or trouble breathing and death.
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Psychotropic and anticonvulsant agents. In, Zimmerman HJ. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. Philadelphia: Lippincott, , pp. Expert review of benzodiazepines and liver injury published in ; mentions rare instances of cholestatic hepatitis have been reported due to alprazolam, chlordiazepoxide, diazepam, flurazepam, and triazolam, and hepatocellular injury with clorazepate and clotiazepam, but no reports of hepatic injury with lorazepam, oxazepam or temazepam.
Larrey D, Ripault MP. Hepatotoxicity of psychotropic drugs and drugs of abuse. Drug-induced liver disease. Amsterdam: Elsevier, , pp. Review of benzodiazepine induced liver injury mentions that increases in liver enzymes during therapy are rare and significant hepatotoxicity uncommon; only a few cases [usually cholestatic] have been reported with alprazolam, chlordiazepoxide, diazepam, flurazepam and triazolam.
Hypnotics and sedatives. New York: McGraw-Hill, , pp. Textbook of pharmacology and therapeutics. Wallace SJ. A comparative review of the adverse effects of anticonvulsants in children with epilepsy. Drug Saf ; Drug- and chemical-induced cholestasis. Clin Liver Dis ; 3: Risk of acute liver injury associated with the use of drugs: a multicentre population survey.
Aliment Pharmacol Ther ; Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology ; Hepatotoxicity associated with antiepileptic drugs.
Acta Neurol Scand ; Incidence, presentation and outcomes in patients with drug-induced liver injury in the general population of Iceland.
Profile of idiosyncratic drug induced liver injury in Latin America. An analysis of published reports. Ann Hepatol ;
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